Comprehensive Guide on Dengue Fever – Symptoms, Tests, Precautions

Complete Guide of Dengue in India

What is Dengue?

Dengue is an infectious and dangerous viral disease found worldwide and is spreading rapidly. It can be deadly in some rare cases. Dengue is transmitted by the bite of the female Aedes aegypti mosquito. These mosquitoes bite during the day or early morning. Dengue fever is also known as breakbone fever due to severe pain in this disease. So be careful when you have a fever and suspected dengue infection, to get it checked immediately.

How Does it Impact our Body?

Dengue can be caused by 4 types of viruses, technically known as DV1, 2, 3 & 4. Generally, when a person suffers from Dengue, he/she develops immunity for that specific virus, but not the other Dengue viruses. If that person suffers from Dengue again (caused by other viruses), this disease can take severe form, so, much more caution and care is needed in cases of such secondary infections.

Our body’s immune system develops certain antibodies (IgM and IgG) in response to this viral infection. You can think of these antibodies as different types of defense teams or army contingents deployed by our body to fight off the enemy i.e. viral infection. So, this is a fight between the enemy soldiers (NS1 antigen) and our soldiers (IgM and IgG antibodies). Our body has a small amount of thousands of different antibodies. Each antibody is highly specialized to recognize a certain kind of foreign substance or antigen. These antibodies bind with antigens to make them inactive, so that other processes of our body can destroy and remove such enemy soldiers from our system.

dengue-ns1-antigen
Dengue NS1 is like enemy soldiers. NS1 enters our body and gives us dengue.

Dengue NS1 Antigen: This is a virus protein that enters our body with the virus and causes infection. This acts like a team of enemy soldiers, who infiltrate into our territory and then cause all kinds of problems, leading to symptoms of dengue viral infection.

igm-antibodies
IgM antibodies are like artillery or heavy tanks that saves us from dengue infection.

IgM Antibodies: These antibodies are produced by our immune system to fight the viral infection. These antibodies are like heavy artillery, e.g. tanks, so the deployment and effect of these antibodies rises with the intensity of viral infection and after a short time, after killing enemy soldiers, these tanks go back or go down in number in our body within 2-3 months. These antibodies are the largest in size and found in blood.

igg-antibodies
IgG antibodies are like commandos sent to kill enemy soldiers and for clean up.

IgG Antibodies: These antibodies are produced by our immune system after some time, almost at the end of viral infection. These antibodies are like commandos, who are sent to clean up, ensure no enemy soldier is left and then protect our body from future infections, so their primary task is to guard against repeat visits of enemy soldiers. These antibodies are the smallest in size so can easily move across cell membranes and found in blood and other body fluids.

In case of secondary dengue infection, IgG antibodies are produced right from the start of infection, along with IgM antibodies. As more firepower is needed, both teams of soldiers – tanks and commandos are deployed right at the start, but tanks (IgM antibodies) don’t increase in numbers as high and remain active for a shorter duration as compared to primary infection. As commandos play a more important role in secondary infection, their number rises sharply in the early phase of infection.

primary-dengue-infection
Sensitivity of dengue tests when dengue occurs for the first time.
secondary-dengue-infections
Sensitivity of dengue tests when dengue occurs for the second time.

(Image Source: http://www.cdc.gov/dengue/clinicallab/laboratory.html)

Types of Dengue

There are three types of dengue – 1) Dengue Fever (DF), 2) Dengue Hemorrhagic Fever (DHF) and 3) Dengue Shock Syndrome (DSS). DHF and DSS are advanced stages of this disease and are found only in about 5% of total dengue cases.

  1. Dengue Fever (DF)

Symptoms of dengue fever are often visible in older children and adults. The fever usually lasts 3 to 7 seven days, but sometimes it may happen again. Main symptoms are as below:

Symptoms of Dengue Fever (DF)

  • Pain in the head and behind the eyes
  • Pain in the joints
  • Bitterness in the mouth
  • Loss of appetite
  • Vomiting and diarrhea
  • Rash on the hands and feet
  • Hair loss
  • Fatigue
  1. Dengue Hemorrhagic Fever (DHF)

Dengue hemorrhagic fever (DHF) is a terrible disease and an advanced form of dengue infection. If somebody suffers from dengue fever again, then the person is more likely to get DHF, which is more dangerous and deadly. So, if this is suspected, the patient should see a good doctor soon. Many symptoms of Dengue hemorrhagic fever (DHF) are similar to those of dengue fever, but later some other symptoms may appear as listed below.

Symptoms of Dengue Hemorrhagic Fever (DHF)

  • Bleeding in gums, nose and skin
  • Internal bleeding or blue or purple marks under the skin
  • Low blood pressure
  • Shock-like illness or coma

These symptoms start showing up 2 to 5 days after the fever. Patient’s health deteriorates rapidly after these symptoms show up and patient may die within 12 to 24 hours so quick action to consult a doctor or hospitalize is important.

  1. Dengue Shock Syndrome (DSS)

DSS is one of the severe conditions of dengue fever, in which patient may go in shock. If the person with dengue shock syndrome (DSS) can be made aware of the symptoms, the patient can be saved with proper treatment. But it is important to hospitalize the patient to ensure proper medical care. The symptoms are:

Symptoms of Dengue Shock Syndrome (DSS)

  • Body and abdominal pain
  • Weak pulse
  • Feeling chills
  • Blood vomiting
  • Mental irritability
  • Fluctuations in body temperature
  • Low blood pressure

If any of these signs appear, then go to the doctor as soon as possible because it may cure fever, otherwise DSS can cause death within 24 hours. When condition of patient becomes serious, the platelets count decreases significantly.

Those who already have had dengue fever in past are more susceptible to suffer from dengue hemorrhagic fever and dengue shock syndrome. Nowadays serology (blood test) and polymer chain reaction (PCR) studies are available, to identify this disease.

Prevention / Treatment of Dengue

Vaccine for Dengue is going through final phases of testing and has been commercially launched in Mexico but is not widely available commercially and not so in India. There is no medicine to specifically treat this viral infection; however medicines can be used to manage the symptoms better as it takes its own time to subside. Following measures, along with drugs prescribed by the doctor may help:

  • Do not let water accumulate at or around your home paying special attention to such cleanliness and hygiene
  • Household utensils to be filled with water should be covered. If properly covered, dengue mosquito will not be able to grow
  • Change the water every day in cooler, pots, etc. and if not needed, water cooler should be emptied and drained
  • Wear clothes that cover your entire body to sleep and use the mosquito net
  • Put kerosene in the water collected at home and use insecticide spraying medicine
  • If small pits near the house are filled with water, then pour soil to avoid stagnant water

Tests for Dengue / Dengue Blood Tests

In line with the immunological response of body, tests for dengue try to identify presence of these antigen (Dengue NS1) or antibodies (IgM and IgG) or the virus type through genetic testing.

  • Dengue Test NS1 Antigen – This test is recommended in the early stage of dengue viral infection as this antigen protein enters our body right from the start. Recommended time period for this test is from 2 to 8 days after infection because after this it may drop to undetectable level. But, please note that dengue NS1 antigen has certain limitations in accuracy.
  • Dengue IgM – This test is recommended 4 to 14 days after you have a fever or other symptoms appear. This is one of the most commonly used tests and presence of Dengue-specific IgM antibodies indicates a recent dengue infection. IgM antibodies may remain high for many days after primary infection as it subsides after around 60-90 days of infection. One important limitation of this test is the cross reactivity with some other viruses, so in regions where some other viruses causing infections name as West Nile virus, Japanese encephalitis virus and Chikungunya virus are prevalent, diagnosis through this test requires caution.
  • Dengue IgG – This test is recommended almost 10-14 days after the onset of symptoms and can be used to identify whether a patient is suffering from primary or secondary infection. A positive IgG result indicates patient had dengue viral infection at some point in past, as these IgG antibodies remain active in our body for a long time. If IgG test result is negative in the initial phase and positive later, it indicates primary infection. Whereas, if IgG test is positive in the initial phase and sensitivity increases more than 4X in at least 7 days, it indicates secondary infection.
  • Dengue PCR – This is a genetic test and can detect the Dengue virus type through detection of virus RNA, so it is considered more accurate and therefore is more expensive also. This test must be conducted in the early phase (also known as febrile/ critical phase) when the virus is active in patient’s body, preferably within 5-7 days of infection.

Due to the overlaps of relevant time periods for these tests, limitations in accuracy and confusion over primary v/s secondary infection, often doctors tend to use Dengue NS1, Dengue IgM and Dengue IgG together to diagnose this infection. When different tests show positive results is displayed in the image below, which also offers an insight into how these test results should be interpreted. Viremia refers to virus identification or Dengue PCR test.

dengue-fever-level
When various dengue tests like NS1, IgG and IgM become positive post dengue infection

(Source: https://en.wikipedia.org/wiki/Dengue_fever#/media/File:Dengue_testing.png)

CBC (Complete Blood Count) Test or Platelet Count Test – Onset of Dengue fever drives down white blood cells and Platelet Count in blood. Dengue virus in the blood of our body seems to change the usual mix of blood so this test is used for preliminary investigation of Dengue and to monitor the platelet count through different phases of this disease.

Cost of Dengue Tests in Delhi NCR

Cost of Dengue test varies for different labs. With the help of LabsAdvisor, you can easily compare these prices and book appointments for Dengue tests. You can click the links provided below to check minimum cost of Dengue blood tests on LabsAdvisor.com and you can book these tests in a lab near you or you can book a Dengue test at home. The link you select will take you to the page with multiple options of diagnostic labs in your vicinity that offer this test.

Min. Price of Dengue Tests In Delhi

Dengue NS1 Antigen Test cost in Delhi / NCR

₹ 600

Dengue IgG Test cost in Delhi / NCR

₹ 575

Dengue IgM Test cost in Delhi / NCR

₹ 575

Dengue IgM & IgG Test cost in Delhi / NCR

₹ 800

Dengue RNA PCR Test cost in Delhi / NCR

₹ 1400

Min. Price of Dengue Tests In Noida

Dengue NS1 Antigen Test cost in Noida

₹ 600

Dengue IGG Test cost in Noida

₹ 575

Dengue IGM Test cost in Noida

₹ 575

Dengue IgM & IgG Test cost in Noida

₹ 640

Dengue RNA PCR Test cost in Noida

₹ 2480

Min. Price of Dengue Tests In Ghaziabad

Dengue NS1 Antigen Test cost in Ghaziabad

₹ 640

Dengue IGG Test cost in Ghaziabad

₹ 575

Dengue IGM Test cost in Ghaziabad

₹ 575

Dengue IgM & IgG Test cost in Ghaziabad

₹ 640

Dengue RNA PCR Test cost in Ghaziabad

₹ 2480

Min. Price of Dengue Tests In Faridabad

Dengue NS1 Antigen Test cost in Faridabad

₹ 600

Dengue IGG Test cost in Faridabad

₹ 575

Dengue IGM Test cost in Faridabad

₹ 575

Dengue IgM & IgG Test cost in Faridabad

₹ 640

Dengue RNA PCR Test cost in Faridabad

₹ 2480

 How will you Book Dengue Tests?

You can book your Dengue tests on www.labsadvisor.com or by calling the customer care number 08882668822. If you want LabsAdvisor team to call you back or provide more information on your email, please fill up your details in the form below or write us at info@labsadvisor.com.

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