A Complete Guide on Thalassemia in India including HPLC Test Cost in India

A Comprehensive Guide on Thalassemia in India / HPLC Test Cost in India

Thalassemia is a blood disorder caused due to inheritance of one or more faulty genes. It is believed that the faulty gene causing Thalassemia originated around the Mediterranean, hence the name which comes from Greek Thalassa meaning ‘sea’.

Currently, about 50% of Thalassemia infected person are from Southeast Asian region (India, Thailand and Indonesia). According to Dr. Sharmila Ghosh, around 12,000 infants being born in India every year with severe disorder. This implies that every hour, 1 child is born who will suffer from this disorder. This calls for an urgent need of diagnosis and hence proper treatment for the disease.

LabsAdvisor.com has compiled the useful information regarding Thalassemia and its diagnostic test, HPLC, to give you proper understanding of the disease. The information is covered under following topics:

  1. What is Thalassemia?
  2. What are the types of Thalassemia?
  3. What are the causes of Thalassemia?
  4. what are the signs and symptoms of Thalassemia?
  5. How Thalassemia can be diagnosed?
  6. Who should be screened for Thalassemia?
  7. What is the cost of a HPLC test in India?
  8. How to book a HPLC test?

What is Thalassemia?

Thalassemia is an inherited blood disorder causing increased destruction of red blood cells. As a result, the patient has low hemoglobin and less red blood cell count. The patient suffers from anemia.

What are the Types of Thalassemia?

Normal hemoglobin also called as hemoglobin has four protein chains, two Alpha globin and two beta globin. Deficiency in these protein chains lead to two types of Thalassemia:

Alpha Thalassemia: Alpha Thalassemia occurs when the body can’t make a protein called alpha globin. To make alpha globin, one needs to have four genes, two from each parent. alpha Thalassemia minor is caused when one or two genes are absent. If three gene are absent then a disease called Hemoglobin H is caused. Absence of all the four gene causes Hydrops fetalis which is extremely severe and occurs before birth. Survival is very rare.

Beta thalassemia: Beta thalassemia occurs when the body can’t produce a protein called beta globin. Two genes including one from each parent, are inherited to make beta globin. Absence of one gene cause thalassemia minor while absence of both the genes will lead to the serious form of disease called as Beta thalassemia major.

According to the severity of the disease, thalassemia can be categorized as:

Thalassemia Major: A child suffering from severe anemia starts depending on blood transfusions throughout its whole life as both the genes producing normal hemoglobin are damaged..

Thalassemia intermedia: It is a less severe form. It develops because of alterations in both beta globin genes. People with thalassemia intermedia do not need blood transfusions.

Thalassemia Minor: it is a mild condition. Usually the patients are asymptomatic or have mild anemia.Thalassemia minor patients are also called as carriers as they carry a faulty gene and are more likely to give birth to thalassemia major babies.

Therefore, HPLC blood test for Thalassemia minor is a must test for pregnant ladies,young people of marriageable age (Premarital counseling) and recently married couples.

What are the Causes of Thalassemia?

Thalassemia is inherited and at least one of the parents must be a carrier of the disease. If both the parents are carriers, then there is one in four chance of their baby to have Thalassemia major. It is not possible to contract Thalassemia from environment and it is not an infectious disease.

Thalassemia Profile Cost in Delhi
LabsAdvisor.com- Thalassemia Profile in India

What are the Sign and Symptoms of Thalassemia?

Patients with beta Thalassemia intermedia have mild to moderate anemia.

Patients with Beta Thalassemia have severe anemia. The signs and symptoms of disease usually occur within the first 2 years of life. They may include health problems, such as:

  • bone deformities, especially in the face
  • dark urine
  • excessive tiredness and fatigue
  • yellow or pale skin
  • Poor appetite, poor growth, tiredness.
  • An enlarged spleen and liver.
  • Bone problems (especially with bones in the face).

How is Thalassemia Diagnosed?

To diagnose the disease, generally HPLC in conjunction with CBC is done. The CBC readings may indicate Thalassemia which is then confirmed by HPLC test.

To know more about CBC Test, click here

What is a HPLC Test?

HPLC is High-Performance Liquid Chromatography. It is gold standard technology for the screening of beta Thalassemia carriers today.

HPLC is a simple blood test to measure ‘Hb A2′ in blood by Hemoglobin CHROMATOGRAPHY. The test does not require any special preparation and can be done at any time of the day.As it is a simple blood test, no risk is involved.

What Does HPLC Result Mean?

If the HbA2 is less than 3.8 then you are not a Thalassemia minor.

If the HbA2 value is more than 3.8, you may be a confirmed case of Thalassemia Minor. Following precautions may be required

  • If you are unmarried, avoid marrying Thalassemia Minor.
  • If you are already married, get your spouse tested for Thalassemia Minor condition.
  • If your spouse is not a Thalassemia Minor, no precaution is required.

 However, if both you and your spouse are carry the Thalassemia trait, consult your doctor for genetic counseling before planning your baby and get diagnosis done to rule out Thalassemia major in the unborn child so the pregnancy can be terminated if you want to.

Who Should be Screened for Thalassemia?

  • Pre-marital youth (18-25 years of age).
  • Newly married couples who are planning to start their family
  • Pregnant women in their first trimester.
  • Parents and extended family of Thalassemia major children or individuals belonging to the high-risk communities.
  • Anybody who has persistent and unexplainable anemia.
  • Any individual with a raised RBC count.

What is the Cost of a HPLC Test in India?

HPLC Test cost varies between ₹ 580 to ₹ 1200. Through LabsAdvisor.com you get a discounted price of HPLC Test for Thalassemia.

Click on the links in the table given below to book your HPLC Test online.

HPLC Test Cost in India LabsAdvisor Min. Cost of HPLC Test  in India
HPLC Test Cost in Delhi ₹ 580
HPLC Test Cost in Noida ₹ 625
HPLC Test Cost in Gurgaon ₹ 560
HPLC Test Cost in Mumbai ₹ 625
HPLC Test Cost in Bangalore ₹ 600
HPLC Test Cost in Hyderabad ₹ 625
HPLC Test Cost in Chennai ₹ 625

Sometimes doctor prescribed Thalassemia Profile in which (CBC, HPLC, Transferrin, Iron Total, TIBC, Ferritin Test) are include.

Thalassemia Profile Cost in India LabsAdvisor Min. Cost of Thalassemia Profile in India
Thalassemia Profile Cost in Delhi ₹ 1350
Thalassemia Profile Cost in Noida ₹ 1350
Thalassemia Profile Cost in Gurgaon ₹ 1350

How to Book a HPLC Test or Thalassemia Profile in India?

You may call LabsAdvisor.com at 08882668822 now to book your HPLC test in India. You can also download our Android App ‘LabsAdvisor’ from Google Play store. If you want a call back, please fill out the form given below.

 

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