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HLA B27 Test Cost & Labs

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HLA B27 Test Price – Flowcytometry₹ 1,260
HLA B27 Test Price – PCR Method₹ 1,550

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HLA B27 Test Price.

Frequently Asked Questions About HLA B27 Test

What is HLA-B27 Test?

HLA-B27 stands for Human Leukocyte antigen B27.  It is a protein found on the outer surface of your white blood cells. HLA helps your immune system differentiate between healthy body tissues and foreign substances that can cause infection.

Most HLA protects your body from harmful foreign invasion. HLA-B27 is a specific type of protein whose presence causes immune system dysfunction.

If HLA-B27 is present on your white blood cell, it can cause your immune system to attack the healthy cells. This type of disorder is called as auto immune disorder or immune mediated disease. The autoimmune diseases associated with HLA-B27 are:

  • ankylosing spondylitis (AS), which is the inflammation of the bones in your spine
  • reactive arthritis, which is the inflammation of your joints, urethra, and eyes, and sometimes results in lesions on your skin
  • juvenile rheumatoid arthritis
  • anterior uveitis, which is the swelling and irritation in the middle layer of your eye

The HLA-B27 test is a blood test that looks for the presence of antigen HLA-B27.

Medical conditions diagnosed using HLA B27 Test.
Uses of HLA B27 Test.

Why is the test ordered?

Your doctor can order an HLA-B27 test if you have following symptoms:

  • joint pain or inflammation of joints
  • inflammation of urethra accompanied by skin lesions.
  • swelling or stiffness of spine, neck or chest
  • recurring inflammation of swelling of middle of the eye.

The HLA-B27 test is initially ordered to help in confirming a suspected diagnosis of ankylosing spondylitis (AS), reactive arthritis, juvenile rheumatoid arthritis (JRA), or sometimes anterior uveitis.

The test itself is not a diagnostic test i.e. it does not definitely confirm or rule out any associated diseases. It just adds a piece of evidence to the signs and symptoms of the auto-immune disorders.

You may also be prescribed an HLA-B27 test if you will be undergoing a kidney or bone marrow transplant. The test will ensure a compatibility match between you and your donor.

What is the procedure of the test?

The test involves drawing of blood from your arm using a small needle. A lab technician will collect the blood sample and send it to the lab for analysis.

What are the preparations required for the test?

As such no special preparation is required as it is a simple blood test. However, do speak to your doctor if you are on some medications to check if you need to stop the medication for the test.

Are there any risks involved?

The HLA27 test carries minimal risks same as those associated with any blood test. They are:

  • difficulty in locating the vein from which sample is to be drawn. This may sometimes result in multiple needle insertion.
  • if you suffer from a blood clot disorder, excessive bleeding can occur at the puncture sight.
  • you may feel light-headedness or experience blackout after the blood is drawn.
  • infection may occur at the puncture site.

The above risks are very rare and can be easily handled.

What does the test result mean?

If an HLA-B27 test is negative, means that the antigen was not detected. Negative test result does not mean that you do not have the suspected condition since people who do not have the antigen can also develop autoimmune diseases.

Likewise, someone who is tested HLA-B27 positive does not necessarily develop one of these conditions. Diagnosis of the autoimmune disorder should be made on the basis of your symptoms and the results of all blood tests. Your doctor will guide you further after receiving your test results.

Researchers are trying to determine the factors or triggers which increases the likelihood of developing the disease in people carrying HLA-B27 antigens.

Possible interpretation of HLA B27 test results.
HLA B27 Test Result.
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HLA B27 Test
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